Director of Engineering

Chicago, IL

Full Time

Senior Manager/Supervisor

Director of Engineering
Compensation: $150K– $200K salary, 0.25% - 0.5% equity stock options
Full benefits, including health coverage, PTO & parental leave

About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.

Role Summary
Own the full hardware (HW) lifecycle for GutLab, from architecture & subsystem integration through manufacturing, validation & deployment for a complex electromechanical device & BOM. Act as final technical authority for GutLab system performance, fleet stability & next generation GutLabs (Gen3) production, combining hands-on engineering depth with strategic judgment to ensure current systems perform reliably in the field & Gen3 scales into manufacturing.

Key Responsibilities:

System Ownership & Development: Own GutLab architecture (electromechanical & fluidic); lead design, testing & refinement via CAD, prototyping & manufacturing
Validation & Deployment Readiness: Own validation, stage gates, documentation & traceability across revisions, firmware & field performance. Lead troubleshooting, diagnostics & closed-loop fixes to eliminate systemic failure modes
End-to-End Execution: Set & execute high standards for all aspects of HW development: procurement, transfer, sustaining engineering & operations
Manufacturing Scale-Up: Drive DFM, design freeze, pilot builds, supplier alignment, cost targets & manufacturing strategy + execution for Gen3
Team Leadership: Mentor & lead a HW team; align resources, timelines & execution to production milestones
Strategic Problem Solving: Address any and all procurement challenges while identifying cost-effective solutions
Cross-Functional Collaboration: Partner with other leaders to align hardware development with broader company strategy & goals

Qualifications

8+ years’ experience in hardware engineering for complex electromechanical systems
Deep proficiency in CAD, tolerances, prototyping & manufacturing

Product lifecycle ownership (concept through transfer & scale-up)
Proven ability to build & manage technical teams
Systems-level troubleshooting expertise across mechanical, fluidic & electronic
Structured, decisive & execution-oriented with high accountability
A strategic thinker who thrives under pressure in fast-paced environments

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Full-time, in-person attendance at BiomeSense's Chicago office (Chicago IL, 60612) is the expectation for this role. Please confirm your willingness to meet this expectation.
If you will require a remote and/or hybrid work schedule instead, please explain below.*

Will you, now or in the future, require visa sponsorship? Note: As of right now, BiomeSense is not sponsoring any new H1-B visas. Please describe what type of sponsorship you'll require, if applicable.*

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Director of Engineering

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