Head of Engineering

Chicago, IL

Full Time

Senior Manager/Supervisor

Head of Engineering
Compensation: $125K– $200K salary, up to 1.0% equity stock options
Full benefits, including health coverage, PTO & parental leave

About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.

Role Summary
Own the full hardware (HW) lifecycle for GutLab, from architecture & subsystem integration through manufacturing, validation & deployment for a complex electromechanical device & BOM. Act as final technical authority for GutLab system performance, fleet stability & next generation GutLabs (Gen3) production, combining hands-on engineering depth with strategic judgment to ensure current systems perform reliably in the field & Gen3 scales into manufacturing.

Key Responsibilities:

System Ownership & Development: Own GutLab architecture (electromechanical & fluidic); lead design, testing & refinement via CAD, prototyping & manufacturing
Validation & Deployment Readiness: Own validation, stage gates, documentation & traceability across revisions, firmware & field performance. Lead troubleshooting, diagnostics & closed-loop fixes to eliminate systemic failure modes
End-to-End Execution: Set & execute high standards for all aspects of HW development: procurement, transfer, sustaining engineering & operations
Manufacturing Scale-Up: Drive DFM, design freeze, pilot builds, supplier alignment, cost targets & manufacturing strategy + execution for Gen3
Team Leadership: Mentor & lead a HW team; align resources, timelines & execution to production milestones
Strategic Problem Solving: Address any and all procurement challenges while identifying cost-effective solutions
Cross-Functional Collaboration: Partner with other leaders to align hardware development with broader company strategy & goals

Qualifications

8+ years’ experience in hardware engineering for complex electromechanical systems
Deep proficiency in CAD, tolerances, prototyping & manufacturing

Product lifecycle ownership (concept through transfer & scale-up)
Proven ability to build & manage technical teams
Systems-level troubleshooting expertise across mechanical, fluidic & electronic
Structured, decisive & execution-oriented with high accountability
A strategic thinker who thrives under pressure in fast-paced environments

Hiring Process Note: We are a small team and we review all resumes, screening questions and assessment scores manually. However this focus on manual review limits our ability to respond to direct messages through LinkedIn and other channels. We appreciate your effort in applying and we thank you for your understanding.

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Full-time, in-person attendance at BiomeSense's Chicago office (Chicago IL, 60612) is the expectation for this role. Please confirm your willingness to meet this expectation.
If you will require a remote and/or hybrid work schedule instead, please explain below.*

Will you, now or in the future, require visa sponsorship? Note: As of right now, BiomeSense is not sponsoring any new H1-B visas. Please describe what type of sponsorship you'll require, if applicable.*

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Head of Engineering

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